The LifeArc Centre for Rare Respiratory Diseases enables leading researchers and clinicians from across the UK to collaborate and share expertise more easily. Together, they are working to discover, develop and deliver new ways of diagnosing and treating rare respiratory diseases. These papers provide a snapshot of some of the areas that our research teams are exploring.
Babaei-Jadidi R et al. mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis. Nature Communications 2025 https://doi.org/10.1038/s41467-025-64036-3
Shakur A et al. Pulmonary cysts as a diagnostic indicator of Birt-Hogg-Dubé syndrome in patients with renal neoplasm. Insights Imaging 2025 Aug 6. https://doi.org/10.1186/s13244-025-02053-y
Yngvadottir B et al. Inherited predisposition to pneumothorax: Estimating the frequency of Birt-Hogg-Dubé syndrome from genomics and population cohorts. Thorax 2025 80(8):553-555. https://doi.org/10.1136/thorax-2024-221738
Mantoan-Ritter L et al. mTOR pathway diseases: challenges and opportunities from bench to bedside. Orphanet J Rare Dis 2025. 20:256. https://doi.org/10.1186/s13023-025-03740-1
Avoseh M et al. Utility of presenting features to differentiate between rare cystic lung diseases. Proceedings of the American Thoracic Society 2025 Jan 29. https://doi.org/10.1513/annalsats.202410-1019rl
